Listed in the NSW Heritage Register, the building is constructed in Sydney sandstone and is one of a row of four significant buildings on Hunter Street that reflects the prosperity of early Newcastle.
After the Newcastle Police Station closed down in 1982, the Hunter Heritage Centre was developed to encourage the participation, appreciation and understanding of Newcastle's unique history, culture and heritage.
In 2007, the Lock-Up was unveiled as the The Lock-Up Cultural Centre. This included the gallery space, museum, and residency program. Since this date, the Lock-Up has had an attendance of over 50,000 people.
In September 2014 The Lock Up re-launched as a dedicated multidisciplinary contemporary arts centre and inner city hub for creative thinking and doing.